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doc. RNDr. Alena Panicucci Zíková, Ph.D.

Position 1 Statutory representative
Institute of Parasitology

Position 2 Head of Laboratory - Laboratory of Functional Biology of Protists
Molecular Parasitology
Institute of Parasitology

Contact details +420 387775482
azikova@paru.cas.cz
PARU II, 2.06

Others

 

Current Position:

2009 – now      Group leader, Institute of Parasitology, Biology Centre ASCR,  České Budějovice, Czech Republic

2013 - now       Lecturer, University of SOuth Bohemia, Faculty of Science, České Budějovice, Czech Republic

2013 & 2016    2 maternity leaves

 

Professional Experience:

2011                research stay supported by EMBO short fellowship at the MRC Mitochondrial Biology Unit, Cambridge, UK; hosting lab: John E. Walker laboratory (6 weeks)

2005 – 2009     postdoctoral scientist, Seattle Biomedical Research Institute, Seattle, USA

2004 – 2005     research stay supported by NATO fellowship at the Seattle Biomedical Research Institute, Seattle, USA; hosting lab: prof. Ken Stuart (6 months)

2001                research stay, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; hosting lab: prof. Rob Benne  (3 months)

 

Education and Academic Qualification:

2006               Ph.D. in Molecular Parasitology, Department of Parasitology, University of South Bohemia, Faculty of Biological Sciences, České Budějovice, Czech Republic

2002                M.Sc. - Master in Parasitology (Cum Laude), University of South Bohemia, Faculty of Biological Sciences, České Budějovice 

 

Honors and Awards received:

2010                Otto Wichterle Prize of the Academy of Sciences of the Czech Republic

2009                L’Oréal National Fellowship For Women In Science

2007                Outstanding PhD thesis, Dean Award, Faculty of Biological Sciences, České Budějovice, Czech Republic

 

 


Teaching Biochemie a molekulární biologie parazitů / Biochemistry and molecular biology of parasites
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Advanced Methods in Molecular Biology
Faculty of Science, University of South Bohemi

Molekulární biologie / Molecular Biology of Cell
Přírodovědecká fakulta Jihočeské univerzity / Faculty of Science, University of South Bohemia

Total found: 61 records
Keough D., Petrová M., King G., Kratochvíl M., Pohl R., Doleželová E., Panicucci Zíková A., Guddat L., Rejman D. (2024) Development of prolinol containing Inhibitors of Hypoxanthine-Guanine-Xanthine phosphoribosy itransferase: rational structure-based drug design Journal of Medicinal Chemistry 67: 7158–7175.
DOI: 10.1021/acs.jmedchem.4c00021
Kovářová J., Moos M., Barrett M., Horn D., Panicucci Zíková A. (2024) The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis PLoS Neglected Tropical Diseases 18: e0012007.
DOI: 10.1371/journal.pntd.0012007
Lukeš J., Speijer D., Panicucci Zíková A., Alfonzo J., Hashimi H., Field M. (2023) Trypanosomes as a magnifying glass for cell and molecular biology Trends in Parasitology 39: 902–912.
DOI: 10.1016/j.pt.2023.08.004

Documents to download:
Lukes_2023_TrendsParasitol (pdf)
Taleva G., Husová M., Panicucci B., Hierro-Yap C., Pineda E., Biran M., Moos M., Butter F., Šimek P., Bringaud F., Panicucci Zíková A. (2023) Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation PLoS pathogens 19: e1011699.
DOI: 10.1371/journal.ppat.1011699
Valach M., Benz C., Aguilar L.C., Gahura O., Faktorová D., Zíková A., Oeffinger M., Burger G., Gray M., Lukeš J. (2023) Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway Nucleic Acids Research 51: 6443–6460.
DOI: 10.1093/nar/gkad422

Documents to download:
Valach_2023_NucAcidRes (pdf)
Wong J., Panicucci Zíková A., Gahura O. (2023) The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a Molecular Biology and Evolution 40: msad146.
DOI: 10.1093/molbev/msad146

Documents to download:
Wong 2023 MolBiolEvol (pdf)
Gahura O., Chauhan P., Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology 38: 1053-1067.
DOI: 10.1016/j.pt.2022.08.010

Documents to download:
Gahura 2022 TrendsParasitol (pdf)
Gahura O., Mühleip A., Hierro-Yap C., Panicucci B., Jain M., Hollaus D., Slapničková M., Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications 13: 5989.
DOI: 10.1038/s41467-022-33588-z

Documents to download:
Gahura 2022 NatCommun (pdf)
Klejch T., Keough D., King G., Doleželová E., Česnek M., Buděšínský M., Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry 65: 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
Lemke C., Jílková A., Ferber D., Braune A., On A., Johe P., Panicucci Zíková A., Schirmeister T., Mareš M., Horn M., Gütschow M. (2022) Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain Chemistry-A European Journal 28: e202201636.
DOI: 10.1002/chem.202201636
Panicucci Zíková A. (2022) Mitochondrial adaptations throughout the Trypanosoma brucei life cycle Journal of Eukaryotic Microbiology 69: e12911.
DOI: 10.1111/jeu.12911
Štěpánek O., Čmoková A., Procházková E. , Grobárová V., Černý J., Slapničková M., Panicucci Zíková A., Kolařík M., Baszczyňski O. (2022) Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens ChemMedChem 17: e202200385.
DOI: 10.1002/cmdc.202200385
Vaňková K., Doleželová E., Tloušťová E., Hocková D., Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry 239: 114559.
DOI: 10.1016/j.ejmech.2022.114559
Cadena L., Gahura O., Panicucci B., Panicucci Zíková A., Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere 16: e0032721.
DOI: 10.1128/mSphere.00327-21

Documents to download:
Cadena_2021_mSphere (pdf)
Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D., Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports 11: 13317.
DOI: 10.1038/s41598-021-91747-6
Gahura O., Hierro-Yap C., Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology 148: 1151–1160.
DOI: 10.1017/S0031182021000202
Hierro-Yap C., Šubrtová , Gahura O., Panicucci B., Dewar C., Chinopoulos C., Schnaufer A., Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry 296: 100357.
DOI: 10.1016/j.jbc.2021.100357
Kalčic F., Frydrych J., Doleželová E., Slapničková M., Pachl P., Slavětínská L.P., Hocková D., Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry 225: 113798.
DOI: 10.1016/j.ejmech.2021.113798
Nguyen V.H., Tichý M., Rožánková S., Pohl R., Doleželová E., Tloušťová E., Slapničková M., Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters 40: 127957.
DOI: 10.1016/j.bmcl.2021.127957
Perlíková P., Krajczyk A., Doleželová E., Slapničková M., Milisavljevic N., Slavětínská L.P., Tloušt'ová E., Gurská S., Džubák P., Hajdúch M., Panicucci Zíková A., Hocek M. (2021) Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides ACS Infectious Diseases 7: 917–926.
DOI: 10.1021/acsinfecdis.1c00062

More publications

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