M.Sc. Pavel Flegontov, C.Sc.
+420 38 777 5526
pavel@paru.cas.cz
UMBR
Mitoproteome of Trypanosoma brucei is now catalogued. But a lot of mitochondrial proteins have completely unknown or poorly defined functions. Some of those obscure proteins appear to be conserved in eukaryotes. We focus on a group of about a dozen conserved proteins, and by making RNAi knockdowns in T. brucei try to get an idea of their functions.
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Total found: 35 records
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Changmai P., Pinhasi R., Pietrusewsky M., Stark M.T., Ikehara-Quebral R.M., Reich D., Flegontov P. (2023) Ancient DNA from Protohistoric Period Cambodia indicates that South Asians admixed with local populations as early as 1st-3rd centuries CE Scientific Report
12: 22507.
DOI: 10.1038/s41598-022-26799-3 |
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Flegontova O., Flegontov P., Jachníková N.,
Lukeš J.,
Horák A. (2023) Water masses shape pico-nano eukaryotic communities of the Weddell Sea Communications Biology
6: 64.
DOI: 10.1038/s42003-023-04452-7 Documents to download: Flegontova_2023_CommBiol (pdf) |
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Butenko A., Opperdoes F.R.,
Flegontova O.,
Horák A., Hampl V., Keeling P., Gawryluk R., Tikhonenkov D.V., Flegontov P.,
Lukeš J. (2020) Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids BMC biology
18: 23.
DOI: 10.1186/s12915-020-0754-1 Documents to download: Butenko_BMC-Biology_2020 (pdf) |
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Flegontova O., Flegontov P.,
Castaňeda Londoňo P., Walczowski W., Śantić D., Edgcomb V.,
Lukeš J.,
Horák A. (2020) Environmental determinants of the distribution of planktonic diplonemids and kinetoplastids in the oceans Environmental Microbiology
22: 4014–4031.
DOI: 10.1111/1462-2920.15190 Documents to download: Flegontova_2020_EnvMicrob (pdf) |
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Polanská N., Ishemgulova A., Volfová V., Flegontov P., Votýpka J.,
Yurchenko V., Volf P. (2020) Sergentomyia schwetzi: Salivary gland transcriptome, proteome and enzymatic activities in two lineages adapted to different blood sources Plos ONE
15: e0230537.
DOI: 10.1371/journal.pone.0230537 Documents to download: Polanska_2020_PloSONE (pdf) |
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Flegontov P., Altınışık E., Changmai P., Rohland N., Mallick S., Adamski N., Bolnick D.A., Broomandkhoshbacht N., Candilio F., Culleton B.J.,
Flegontova O., Friesen T.M., Jeong Ch., Keating D., Kennett D.J., Kim A.M., Lamnidis T.C., Lawson A.M., Olalde I., Oppenheimer J., Potter B.A., Raff J., Sattler R.A., Skoglund P., Stewardson K., Vajda E.J., Vasilyev S., Veselovskaya E., Hayes G., O’Rourke D.H., Krause J., Pinhasi R., Reich D., Schiffels S. (2019) Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America Nature
570: 236–240.
DOI: 31168094 |
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Jeong A., Balanovsky O., Lukianova E., Flegontov P., Zaporozhchenko V., Wang C.C., Ixan O., Khussainova E., Bekmanov B., Zaibert V., Lavryashina M., Pocheshkhova E. , Yusupov Y., Agdzhoyan A., Koshel S., Bukin A. (2019) The genetic history of admixture across inner Eurasia Nature Ecology and Evolution
6: 966–976.
DOI: 10.1038/s41559-019-0878-2 |
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Flegontova O., Flegontov P., Malviya S., Poulain J., de Vargas C., Bowler C.,
Lukeš J.,
Horák A. (2018) Neobodonids are dominant kinetoplastids in the global ocean Environmental Microbiology
20: 878-889.
DOI: 10.1111/1462-2920.14034 Documents to download: Flegontova_et.al_2018 (pdf) |
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Gerasimov E.S., Gasparyan A.A.,
Kaurov I., Tichý B., Logacheva M., Kolesnikov A.,
Lukeš J.,
Yurchenko V., Zimmer S., Flegontov P. (2018) Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool Nucleic Acids Research
46: 765-781.
DOI: 10.1093/nar/gkx1202 Documents to download: Gerasimov et al. 2018 (pdf) |
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Kutanan W., Kampuansai J.,
Changmai P., Flegontov P., Schröder R., Macholdt E., Hübner A. , Kangwanpong D., Stoneking M. (2018) Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand Scientific Reports
8: 1536.
DOI: 10.1038/s41598-018-20020-0 |
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Lipson M., Cheronet O., Mallick S., Rohland N., Oxengam M., Pietrusewsky M., Pryce T.O., Willis A., Matsumura H., Buckey H., Domett K., Nguyen G.H., Trinh H.H., Kyaw A.A., Win T.T., Pradier B., Broomandkhoshbacht N., Candilio F.,
Changmai P., Fernandes D., Ferry M., Gamarra B., Harney E., Kampuansai J., Kutanan W., Michel M., Novak M., Oppenheimer J., Sirak K., Stewardson K., Zhang Z., Flegontov P., Pinhasi R., Reich D. (2018) Ancient genomes document multiple waves of migration in Southeast Asian prehistory Science
361: 92–95.
DOI: 10.1126/science.aat3188 |
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Ishemgulova A.,
Butenko A., Kortišová L., Boucinha C., Grybchuk-Ieremenko A., Morelli K.,
Tesařová M., Kraeva N., Grybchuk D., Pánek T., Flegontov P.,
Lukeš J.,
Votýpka J., Pavan M.G., Opperdoes F., Spodareva V., D'avila-Levy C., Kostygov A.,
Yurchenko V. (2017) Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila PLoS ONE
12: e0174165.
DOI: 10.1371/journal.pone.0174165 Documents to download: Ishemgulova et al. 2017 PLoS ONE (pdf) |
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Kılınç G.M., Koptekin D., Atakuman Ç., Sümer A.P., Dönertaş H.M., Yaka R., Bilgin C.C., Büyükkarakaya A.M., Baird D., Altınışık E., Flegontov P., Götherström A., Togan I., Somel M. (2017) Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean Proceedings Of The Royal Society B-Biological Sciences
284: 20172064.
DOI: 10.1098/rspb.2017.2064 |
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Kostygov A. ,
Butenko A.,
Nenarokova A.,
Tashyreva D., Flegontov P.,
Lukeš J.,
Yurchenko V. (2017) Genome of Ca. Pandoraea novymonadis, an Endosymbiotic Bacterium of the Trypanosomatid Novymonas esmeraldas Frontiers in Microbiology
8: 1940.
DOI: 10.3389/fmicb.2017.01940 Documents to download: Kostygov et al. 2017 FiM (pdf) |
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Skalický T.,
Dobáková E., Wheeler R.J.,
Tesařová M., Flegontov P.,
Jirsová D.,
Votýpka J.,
Yurchenko V., Ayala F.,
Lukeš J. (2017) Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid Proceedings of the National Academy of Sciences of the United States of America
114: 11757-11762.
DOI: 10.1073/pnas.1712311114 Documents to download: Skalicky et al. 2017 PNAS (pdf) |
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Tanifuji G., Cenci U., Moog D., Dean S., Nakayama T.,
David V.,
Fiala I., Curtis B., Sibbald S.J., Onodera N., Colp M., Flegontov P., Johnson-MacKinnon J., McPhee M., Inagaki Y., Hashimoto T., Kelly S., Gull K.,
Lukeš J., Archibald J. (2017) Genome sequencing reveals metabolic and cellular interdependence in an amoebakinetoplastid symbiosis Scientific Reports
7: 11688.
DOI: 10.1038/s41598-017-11866-x Documents to download: Tanifuji et al. 2017 SR (pdf) |
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Flegontov P.,
Butenko A.,
Firsov S., Kraeva N., Eliáš M., Field M., Filatov D.,
Flegontova O., Gerasimov E.S., Hlaváčová J., Jackson A.,
Ishemgulova A., Kelly S., Kostygov A., Logacheva M., Maslov D., Opperdoes F., O’Reilly A., Sádlová J., Ševčíková T., Venkatesh D., Vlček Č., Volf P.,
Votýpka J., Záhonová K.,
Yurchenko V.,
Lukeš J. (2016) Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania Scientific Reports
6: 23704.
DOI: 10.1038/srep23704 Documents to download: Flegontov et al. 2016 SR6:23704 (pdf) |
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Flegontov P.,
Changmai P., Zidkova A., Logacheva M., Logacheva M.,
Flegontova O., Nikolsky Y., Starostin G., Stepanova V., Travinsky I., Tříska M., Tříska P., Tatarinova T. (2016) Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry Scientific Reports
6: 20768.
DOI: 10.1038/srep20768 Documents to download: Flegontov et al. 2016 Scientific Reports (pdf) |
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Flegontov P., Kassian A., Thomas M., Fedchenko V.,
Changmai P., Starostin G. (2016) Pitfalls of the Geographic Population Structure (GPS) Approach Applied to Human Genetic History: A Case Study of Ashkenazi Jews Genome Biology and Evolution
8: 2259-2265.
DOI: 10.1093/gbe/evw162 Documents to download: Flegontov et al. 2016 GBE (pdf) |
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Flegontova O., Flegontov P., Malviya S., Audic S., Wincker P., de Vargas C., Bowler C.,
Lukeš J.,
Horák A. (2016) Extreme diversity of diplonemid eukaryotes in the ocean Current Biology
26: 3060-3065.
DOI: 10.1016/j.cub.2016.09.031 Documents to download: Flegontova et al. 2016 CB (pdf) |
