RNDr. Luděk Eyer, Ph.D.
Research Scientist - Laboratory of Arbovirology
Disease Vectors and Pathogens
Institute of Parasitology
+420 533331911
eyer@vri.cz
316
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Total found: 39 records
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Holoubek J.,
Salát J., Kotouček J., Kastl T.,
Vancová M., Huvarová I., Bednář P., Bednářová K.,
Růžek D., Renčiuk D., Eyer L. (2024) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research
221: 105767.
DOI: 10.1016/j.antiviral.2023.105767 |
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Vojnikova M., Sukupová M., Štefánik M.,
Straková P., Haviernik J., Kapolkova K., Gruberova E., Raskova K., Michalkova H., Švec P., Kudlickova M.P., Huvarová I.,
Růžek D.,
Salát J., Pekarik V., Eyer L., Heger Z. (2024) Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin International Journal of Nanomedicine
19: 3907–3917.
DOI: 10.2147/IJN.S452119 |
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Eyer L., Seley-Radtke K.,
Růžek D. (2023) New directions in the experimental therapy of tick-borne encephalitis Antiviral Research
210: 105504.
DOI: 10.1016/j.antiviral.2022.105504 |
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Holoubek J.,
Salát J., Kotouček J., Kastl T.,
Vancová M., Huvarová I., Bednář P., Bednářová K.,
Růžek D., Renčiuk D., Eyer L. (2023) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research
221: 105767.
DOI: 10.1016/j.antiviral.2023.105767 |
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Kobayashi S., Fukuda Y., Yoshii K., Thammahakin P., Maezono K., Eyer L.,
Růžek D., Kariwa H. (2023) Development of recombinant West Nile virus expressing mCherry reporter protein Journal of Virological Methods
37: 114744.
DOI: 10.1016/j.jviromet.2023.114744 |
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Mariewskaya K.A., Gvozdev D.A., Chistov A.A.,
Straková P., Huvarová I.,
Svoboda P., Kotouček J., Ivanov N.M., Krasilnikov M.S., Zhitlov M.Y., Pak A.M., Mikhnovets I.E., Nikitin T.D., Korshun V.A., Alferova V.A., Mašek J.,
Růžek D., Eyer L., Ustinov A.V. (2023) Membrane-targeting perylenylethynylphenols inactivate medically important coronaviruses via the singlet oxygen photogeneration mechanism Molecules
28: 6278.
DOI: 10.3390/molecules28176278 |
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Mikhnovets I.E.,
Holoubek J., Panina I.S., Kotouček J., Gvozdev D.A., Chumakov D.A., Krasilnikov M.S., Zhitlov M.Y., Gulyak E.L., Chistov A.A., Nikitin T.D., Korshun V.A., Efremov R.G., Alferova V.A.,
Růžek D., Eyer L., Ustinov A.V. (2023) Alkyl derivatives of perylene photosensitizing antivirals: towards understanding the influence of lipophilicity International Journal of Molecular Sciences
24: 16483.
DOI: 10.3390/ijms242216483 |
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Penjarla S., Reddy P.Y., Penta S., Sanghvi Y., Eyer L., Štefánik M., Krátká Z.,
Růžek D., Banerjee S. (2023) Synthesis and antiviral activity of 2′-modified L-nucleoside analogues ChemistrySelect
8: e202303585.
DOI: 10.1002/slct.202303585 |
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Penjarla S., Reddy P.Y., Penta S., Sanghvi Y.S., Eyer L., Štefánik M.,
Růžek D., Banerjee S. (2023) Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity Journal of Molecular Structure
1292: 136099.
DOI: 10.1016/j.molstruc.2023.136099 |
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Straková P., Bednar P., Kotouček J.,
Holoubek J., Fořtová A.,
Svoboda P., Štefánik M., Huvarová I., Simeckova P., Korshun V.A.,
Růžek D., Eyer L. (2023) Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation Virus Research
334: 199158.
DOI: 10.1016/j.virusres.2023.199158 |
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Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B., Eyer L.,
Hönig V.,
Palus M.,
Růžek D.,
Vyhlídalová T.,
Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine
76: 103818.
DOI: 10.1016/j.ebiom.2022.103818 |
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Štefánik M., Bhosale D.,
Straková P.,
Haviernik J., Fojtikova M., Dufkova L., Huvarová I.,
Salát J.,
Růžek D., Miller A., Eyer L. (2022) Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses Viruses-Basel
14: 354.
DOI: 10.3390/v14020354 |
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Thames J.E., Eyer L., Seley-Radtke K. (2022) Small molecule-based inhibitors for treatment of tick-borne encephalitis virus infection: Nucleoside analogs and nonnucleoside antivirals, Chapter II. In: D.I. Osolodkin (Ed.), Annual Reports in Medicinal Chemistry, Medicinal Chemistry of Tick-Borne Encephalitis.
256: 58: 55-92.
DOI: 10.1016/bs.armc.2022.08.003 |
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Dejmek M., Konkolová E., Eyer L.,
Straková P.,
Svoboda P., Šála M., Krejčová K.,
Růžek D., Boura E., Nencka R. (2021) Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication Viruses-Basel
8: 1585.
DOI: 10.3390/v13081585 |
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Eyer L., Svoboda P., Balvan J., Vičar T., Raudenská M., Štefánik M., Haviernik J., Huvarová I., Straková P., Rudolf I., Hubálek Z., Seley-Radtke K., De Clercq E.,
Růžek D. (2021) Broad-spectrum antiviral activity of 3′-Deoxy-3′-fluoroadenosine against emerging flaviviruses Antimicrobial Agents and Chemotherapy
65: e01522-20.
DOI: 10.1128/AAC.01522-20 |
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Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J.,
Palus M., de Lamballerie X., Gould E.,
Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
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Milisavljevic N., Konkolová E., Kozák J., Hodek J., Veselovská L., Čížek K., Pohl R., Eyer L., Svoboda P.,
Růžek D., Weber J., Nencka R., Boura E., Hocek M. (2021) Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases
76: 471–478.
DOI: 10.1021/acsinfecdis.0c00829 |
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Štefánik M., Straková P., Haviernik J., Miller A.,
Růžek D., Eyer L. (2021) Antiviral activity of vacuolar atpase blocker diphyllin against sars-cov-2 Microorganisms
9: 471.
DOI: 10.3390/microorganisms9030471 |
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Gejji V. , Svoboda P., Štefánik M., Wang H., Salát J., Eyer L.,
Růžek D., Fernando S. (2020) An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus(Article) Virology
546: 13–19.
DOI: 10.1016/j.virol.2020.03.006 |
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Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J.,
Palus M., de Lamballerie X., Gould E.,
Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
